|
KMID : 1123920150290050422
|
|
Korean Journal of Oriental Physiology and Pathology
2015 Volume.29 No. 5 p.422 ~ p.433
|
|
|
Anti-hyperlipidemic and Anti-oxidant effects of Kgihwaetang-gamibang in High Cholesterol Diet-induced Mice Model
|
|
Shin Yong-Jeen
Jeon Sang-Yun
|
|
|
Abstract
|
|
|
|
This study was conducted to investigate the anti-hyperlipidemic and anti-oxidative activities of Ikgihwaetang-gamibang (IK). We observed the effect of IK on lipid factor, inflammation factor, body weight and organ weight, and liver after administering IK to hyperlipidemia mice triggered by high fat diet. Additionally, we used Raw 264.7 cells to investigate the changes in anti-oxidative activity and the effects of anti-inflammation. Administration of IK resulted in reduction of total cholesterol, LDL cholesterol, TG, and glucose in blood serum while a clear increase in HDL cholesterol. The production of IL-1β and IL-6, and ROS and NO also decreased. The results showed that IK has anti-hyperlipidemic and anti-oxidative effects, and suggested its potential use in prevention and treatment of hyperlipidemia and its associated diseases.
|
|
|
KEYWORD
|
|
|
Ikgihwaetang-gamibang, Hyperlipidemia, HDL Cholesterol, Anti-oxidation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|